Schistosomiasis has been associated with increased HIV acquisition. Yegorov et al. explored the impact of S. mansoni treatment on HIV susceptibility and discovered that schistosomiasis therapy reduced ex vivo HIV viral entry into both mucosal and systemic CD4+ T cells. Transcriptomic analysis identified up-regulation of global interferon IFN-I pathways and antiviral genes post-Sm treatment, which help explain reduced HIV infectivity. These findings could help guide HIV prevention programs in regions with high endemic disease burden.
Kramer et al. provide the first genome-level exploration into the secondary metabolite potential of the Hyphodiscus fungal genus and discover a novel, light-induced metabolite, hyphodiscorubrin. The researchers demonstrate that the natural product potential of filamentous fungi can be much greater than the bioactivity captured during analysis of extracts grown in standard laboratory conditions.
Highlights from the first iteration of the PRiME COVID-19 mini symposium established to showcase research recently funded by the Toronto COVID-19 Action Fund. Funded projects include the development of core facilities and open access resources, and research on novel antiviral drug targets, identification of host dependency factors, and the advancement of diagnostic and serological tests.
Plant pathogens represent a major threat to global ecosystems and the agricultural industry. Similar to all microbial niches, plant pathogens must adapt to their environment, including navigating the geographical range and immune defense of their host (Jones & Dangl, 2006). Characterizing the mechanisms underlying host-pathogen interactions are crucial for the development of engineered, broadly resistant crops.
Tam et al. uncover an unexpected role for intestinal bile acids in directly binding to and inhibiting C. difficile toxin function providing a framework for the development of novel anti-toxin therapeutics.