Increased resistance to current antiretroviral therapies requires discovery of alternate measures for HIV treatment. Wong et al. identified 5342191 as a compound that restricts viral replication through activation of host intracellular signaling. Findings were replicated in both wild-type and HIV-resistant strains, making 5342191 a promising candidate for future treatments.
Schistosomiasis has been associated with increased HIV acquisition. Yegorov et al. explored the impact of S. mansoni treatment on HIV susceptibility and discovered that schistosomiasis therapy reduced ex vivo HIV viral entry into both mucosal and systemic CD4+ T cells. Transcriptomic analysis identified up-regulation of global interferon IFN-I pathways and antiviral genes post-Sm treatment, which help explain reduced HIV infectivity. These findings could help guide HIV prevention programs in regions with high endemic disease burden.