The link between IBD and colon cancer is widely accepted. Irrazabal et al. establish a fascinating mechanistic link between these two devastating diseases. The pathobionts underlying IBD produce metabolites which lead to the increased production of reactive oxygen species, damaging the host DNA, and leading to tumorigenesis. Promisingly, the authors find that antioxidants can effectively treat this is mouse models.
Plant pathogens represent a major threat to global ecosystems and the agricultural industry. Similar to all microbial niches, plant pathogens must adapt to their environment, including navigating the geographical range and immune defense of their host (Jones & Dangl, 2006). Characterizing the mechanisms underlying host-pathogen interactions are crucial for the development of engineered, broadly resistant crops.