Tam et al. uncover an unexpected role for intestinal bile acids in directly binding to and inhibiting C. difficile toxin function providing a framework for the development of novel anti-toxin therapeutics.
This post features the work McLeod et al. recently published in Nature Communications, highlighting a creative approach to anti-malaria vaccine development. Specifically, the researchers identify the most potent antibody to date against the Plasmodium surface protein Pfs25 and use molecular characterization to provide valuable insights into the vaccine-antibody interaction.