While NOD2 mutations are linked to Crohn's disease occurrence, the exact mechanism by which loss of NOD leads to intestinal inflammation is unclear. Here, Prescott et al demonstrate a possible mechanism by which NOD induces an anti-inflammatory microenvironment with CD103+ Dendritic Cells, possibly opening a avenue for Crohn’s disease therapy.
The link between IBD and colon cancer is widely accepted. Irrazabal et al. establish a fascinating mechanistic link between these two devastating diseases. The pathobionts underlying IBD produce metabolites which lead to the increased production of reactive oxygen species, damaging the host DNA, and leading to tumorigenesis. Promisingly, the authors find that antioxidants can effectively treat this is mouse models.