Crohn’s and NOD2: A Classic Interaction Re-Examined

While NOD2 mutations are linked to Crohn's disease occurrence, the exact mechanism by which loss of NOD leads to intestinal inflammation is unclear. Here, Prescott et al demonstrate a possible mechanism by which NOD induces an anti-inflammatory microenvironment with CD103+ Dendritic Cells, possibly opening a avenue for Crohn’s disease therapy.

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