My research focuses on the regulation of RNA processing with particular emphasis in the context of HIV-1 and other viruses. Our studies to date have demonstrated the use of small molecular modulators of RNA processing as potent antivirals, suggesting a novel approach to the treatment of these infections.

Selected publications:

1. Wong, R, Lingwood, C., Ostrowski, M., Cabral, T., and Cochrane, A. (2018). Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling. Nature Scientific Reports 8, 850 DOI:10.1038/s41598-018-19298-
2. Balachandran, A., Wong, RW, Stoilov, P., Pan, S., Blencowe, B., Cheung, P., Harrigan, R., and Cochrane, A. (2017). Identification of Small Molecule Modulators of HIV-1 Tat and Rev Protein Accumulation. Retrovirology 14(1):7. doi: 10.1186/s12977-017-0330-0.
3. Shkreta, L. ; Blanchette, M. ; Toutant, J. ; Wilhem, E. ; Bell, B. ; Cochrane, A. ; McArthur, S.; Harrigan, P.R. ; Cheung, P.K.; Grierson, D.S. ; Chabot, B. (2017) A novel compound that blocks HIV-1 replication inhibits the splicing regulatory function of SRSF10. NAR 45(7):4051-4067
4. Wong, R., Balachandran, A., Haaland, M., Parsons, M., Ostrowski, M., Stoilov, P., and Cochrane, A. (2013). Characterization of Novel Inhibitors of HIV-1 Replication that Function Via Alteration of Viral RNA Processing and Rev Function. NAR 41, 9471-9483.