Epstein-Barr virus (EBV) is herpesvirus that infects most people and is maintained for life due to interplay between latent and lytic modes of infection. While often asymptomatic, EBV can cause several cancers due to its ability to efficiently immortalize cells. EBV encodes ~80 proteins, many of which are uncharacterized but thought to function to manipulate cellular processes, including cell cycle progress, DNA damage responses and ubiquitin and SUMO modification pathways. My lab is determining the roles of EBV proteins in host cell manipulation as well as identifying cellular factors that restrict and regulate EBV infection.

Selected publications:

1. De La Cruz-Herrera, C.F., Shire, K., Siddiqi, U.Z. and Frappier, L. 2018 A Genome-wide Screen of Epstein-Barr Virus Proteins that Modulate Host SUMOylation Identifies a SUMO E3 Ligase conserved in Herpesviruses. PLoS Pathogens. 17(4), e1007176. PMID:29979787
2. Ho,T-H., Sitz, J., Shen, Q., Leblanc-Lacroix, A., Campos, E. I., Borozan, I., Marcon, E., Greenblatt, J., Fradet-Turcotte, A., Jin, D-Y. and Frappier, L. 2018 A Screen for Epstein-Barr Virus Proteins that Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein. J. Virol. JVI.00262-18. PMID: 29743367
3. Mansouri, S., Pan, Q., Blencowe, B., Claycomb, J. and Frappier, L. 2014 The Epstein-Barr Virus EBNA1 Protein Regulates Viral latency Through Effects on Let-7 microRNA and Dicer. J. Virol. 88, 11166-11177. PMID:25031339
4. Paladino, P., Marcon, E., Greenblatt, J. and Frappier, L. 2014 Identification of Herpesvirus Proteins that Contribute to G1/S Arrest. J. Virol. 88, 4480-4492. PMID:24501404
5. Salsman, J., Zimmerman, N., Chen, T., Domagala, M. and Frappier, L. 2008. Genome-wide Screen of Three Herpesviruses for Protein Subcellular Localization and Alteration of PML Nuclear Bodies. PLoS Pathogens 4(7): e1000100. PMID: 18617993