IBD – MicrobeTO

Crohn’s and NOD2: A Classic Interaction Re-Examined

Post author:MicrobeTO
Post published:November 4, 2020
Post category:Research Highlight

While NOD2 mutations are linked to Crohn's disease occurrence, the exact mechanism by which loss of NOD leads to intestinal inflammation is unclear. Here, Prescott et al demonstrate a possible mechanism by which NOD induces an anti-inflammatory microenvironment with CD103+ Dendritic Cells, possibly opening a avenue for Crohn’s disease therapy.

Using Antioxidants to Treat Bacterial-Induced Colorectal Cancer

Post author:MicrobeTO
Post published:June 30, 2020
Post category:Research Highlight

The link between IBD and colon cancer is widely accepted. Irrazabal et al. establish a fascinating mechanistic link between these two devastating diseases. The pathobionts underlying IBD produce metabolites which lead to the increased production of reactive oxygen species, damaging the host DNA, and leading to tumorigenesis. Promisingly, the authors find that antioxidants can effectively treat this is mouse models.