Thierry Mallevaey, PhD

Associate Professor
Department(s): Immunology
Location: Medical Science Building
Email: Thierry.mallevaey@utoronto.ca

Our current research focuses on host-microbe interactions, and how it relates to intestinal inflammation. Specifically, we study the reciprocal interactions between commensal, pathobiontic and pathogenic microbes and innate lymphocytes such as natural killer T (NKT) cells and mucosa-associated invariant T (MAIT) cells.

Selected publications:

  1. The common mouse protozoa Tritrichomonas muris alters mucosal T cell homeostasis and colitis susceptibility. Escalante NK, Lemire P, Cruz Tleugabulova M, Prescott D, Mortha A, Streutker CJ, Girardin SE, Philpott DJ, Mallevaey T. J Exp Med. 2016 Dec 12;213(13):2841-2850.
  2. NKT Cell-Deficient Mice Harbor an Altered Microbiota That Fuels Intestinal Inflammation during Chemically Induced Colitis. Selvanantham T, Lin Q, Guo CX, Surendra A, Fieve S, Escalante NK, Guttman DS, Streutker CJ, Robertson SJ, Philpott DJ, Mallevaey T. J Immunol. 2016 Dec 1;197(11):4464-4472.
  3. Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection. Selvanantham T, Escalante NK, Cruz Tleugabulova M, Fiévé S, Girardin SE, Philpott DJ, Mallevaey T. J Immunol. 2013 Dec 1;191(11):5646-54.
  4. Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Paget C, Mallevaey T, Speak AO, Torres D, Fontaine J, Sheehan KC, Capron M, Ryffel B, Faveeuw C, Leite de Moraes M, Platt F, Trottein F. Immunity. 2007 Oct;27(4):597-609.
  5. Activation of invariant NKT cells by the helminth parasite schistosoma mansoni. Mallevaey T, Zanetta JP, Faveeuw C, Fontaine J, Maes E, Platt F, Capron M, de-Moraes ML, Trottein F. J Immunol. 2006 Feb 15;176(4):2476-85.
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