My research is focussed in the areas of Microbial metabolism, Metabolic Engineering, Systems Biology, Synthetic Biology. Application areas include synthesis of renewable chemicals and therapeutic small molecules. Another focus of my research group is in the area of metabolism and physiology of microbial communities with the idea of engineering them for applications in bioremediation and gut microbiome.

Selected Publications:

1. Partow, S., Hyland, P. B., & Mahadevan, R. (2017). Synthetic rescue couples NADPH generation to metabolite overproduction in Saccharomyces cerevisiae. Metabolic Engineering, 43, 64-70. doi:10.1016/j.ymben.2017.08.004.
2. Pandit AV, Srinivasan S, Mahadevan R. Redesigning metabolism based on orthogonality principles. Nature Communications 2017;8:15188
3. N. Anesiadis, H.Kobayashi, W. R. Cluett, R. Mahadevan, “Analysis and design of a genetic circuit for dynamic metabolic engineering”, 2013, ACS Synthetic Biology,2(8):442-52.
4. K. Zhuang, G. Vemuri, R. Mahadevan, "Economics of Membrane Occupancy and the Respiro-fermentation,” Molecular Systems Biology, 2011, 7:500.
5. Zhuang, K., Izallalen, M., Mouser, P., Richter, H., Risso, C., Mahadevan, R., & Lovley, D. R. (2010). Genome-scale dynamic modeling of the competition between Rhodoferax and Geobacter in anoxic subsurface environments. The ISME Journal, 5(2), 305-316. doi:10.1038/ismej.2010.117.